The aim of our software suite ARES is to support neurosurgeons in the the estimation of aneurysm rupture risk. For this we take the complete blood count (hemogram) as an example. Instead of using measurement equipment in a lab we use computers to "measure" characteristic parameters in the virtual world.
hemodynamic (e.g. wall shear stress, oscillatory shear index etc…)
structural mechanic (strain, stress etc…)
A fully developed GUI by our partner RISC Software GmbH (Hagenberg, Austria) can be used by neurosurgeons without simulation experience for
segmentation of the aneurysm
user input
visualization of results
eulerian-solutions e.U. is responsible for the development of Fluid-Structure Interaction (FSI) simulations. This simulation runs fully automated in the background without required user input.
based on the open source Computational Fluid Dynamics Tool OpenFoam
If you are interested in medical solutions, please fill out the contact form below.
Simulation results
In FSI simulations with the software suite ARES it is possible to visualize morphologic, hemodynamic as well as structural mechanical properties.
Simulations are automatically set up and run in the background.
Neurosurgeons do not have to have simulation experience in order to use the software suite.
Possibility to visualize
wall shear stress
oscillatory shear index (OSI)
Vessel wall Mises stress
Many more...
If you are interested in medical solutions, please fill out the contact form below.
Statistical evaluation
We conduct statistic evaluation of a dataset of over 450 patients treated at the Kepler Universitätsklinikum (Linz, Austria) between 2016 and 2023.
Test for normal distribution
no normal distribution of data found
Box plot examples
Morphologic parameter: curvature
Hemodynamic parameter: maximum oscillatory shear index
Structural mechanic parameter: maximum Mises stress
Mann-Whitney U-Test for p-value
significant difference if p is less then 0.05
Compare ruptured and stable aneurysms
Neurosurgeons can use results in patient care and education
Does patient's aneurysm behave like most ruptured or stable aneurysm?
Can lead to better patient understanding regarding the sererity of the situation and the neccessity of treatment
Scientific publications
With our rigorous research we also validate our findings by publishing them in internationally acclaimed and peer reviewed journals:
J. Nagy, W. Fenz, S. Thumfart, J. Maier, Z. Major, H. Stefanits, M. Gollwitzer, J. Oberndorfer, N. Stroh, M. Giretzlehner, M. Sonnberger, A. Gruber, P.R. Rauch, M. Gmeiner. Fluid structure Interaction analysis for rupture risk assessment in patients with middle cerebral artery aneurysms, Sci Rep. 2025 Jan 14;15(1)1965., https://doi.org/10.1038/s41598-024-85066-9
J. Nagy, W. Fenz, V. Miron, S. Thumfart, J. Maier, Z. Major, H. Stefanits, J. Oberndorfer, N. Stroh, V. Mazanec, P.R. Rauch, A. Gruber, M. Gmeiner. Fluid–Structure Interaction Simulations of the Initiation Process of Cerebral Aneurysms, Brain Sci. 2024, 14, 977., https://doi.org/10.3390/brainsci14100977
J. Nagy, J. Maier, W. Fenz, Z. Major, A. Gruber, M. Gmeiner. Analysis of Morphology, Hemodynamics and Structural Mechanics for the Establishment of Growth History of Cerebral Aneurysm, JBEB, 11: 8-13, 2024 September, https://doi.org/10.11159/jbeb.2024.002
J. Nagy, J. Maier, V. Miron, W. Fenz, Z. Major, A. Gruber, M. Gmeiner. Methods, Validation and Clinical Implementation of a Simulation Method of Cerebral Aneurysms, JBEB, 10: 10-19, 2023 Oktober, https://doi.org/10.11159/jbeb.2023.003
If you are interested in further publications by Jozsef Nagy you can find an extensive list here: publications
Contact eulerian-soltuions e.U. in order to learn more about medical applications
If you are interested in the medical applications by eulerian-solutions e.U. and affiliated partners please fill out the contact form below: